熊亮，男，博士，博士后，研究员，硕士研究生导师，博士毕业于清华大学北京协和医学院&中国医学科学院药物研究所，现担任成都中医药大学“西南特色药材创新药物成分研究所”所长，2013年破格晋升副研究员，2016年破格晋升研究员。获得四川省杰出青年基金，入选四川省学术技术带头人后备人选、四川省卫生计生委学术技术带头人后备人选、四川省中医药学术技术带头人后备人选、四川省食品药品监督管理局药品注册核查专家、四川省药品安全专家委员会专家、四川省科技专家库专家、成都中医药大学青年英才、世界中联中药上市后再评价专业委员会“常务理事”、中国民族医药学会信息与大数据分会“常务理事”。

基于西南丰富的中药资源，关注活血类中药防治妇产科疾病和脑血管疾病领域，针对中医优势病种偏头痛、月经不调、痛经、产后复旧不良等，围绕益母草、川芎、姜黄、蓬莪术、红花等川产活血化瘀药材，开展系统的物质基础及创新药物发现研究。近年来，共获得900多个化学成分，其中新化合物300余个，新骨架化合物18个，发现一系列具有显著活性的中药成分，并对多种中药材及饮片开展质量标准研究，对已上市中成药品种进行二次开发研究。主持国家自然科学基金 2 项、中国博士后科学基金、四川省杰出青年基金、四川省应用基础研究等项目，主研国家自然基金重点项目、国家重大新药创制专项等重要项目。发表学术论文100余篇，其中SCI论文46篇，单篇最高引用 117 次；出版专著 4 部，其中副主编 3 部（含“十三五”规划教材 1 部）；获得授权专利11项；荣获四川省科技进步奖一等奖1次，华夏医学科技奖二等奖1次。

近年来承担的主要课题

1.  国家自然科学基金，基于Sp1调控VEGFR2基因转录及蛋白泛素化水平的益母草促血管生成药效物质与作用机制研究(81872991)，2019/1-2022/12，主持。

2.  国家自然科学基金，基于生物碱及肽类成分研究益母草缩宫止血的药效物质基础(81303209)，2014/1-2016/12，主持。

3.  四川省杰出青年基金，广藿香油中抗耐药菌新颖倍半萜的发现与研究(2015JQO030)， 2015/1-2017/12，主持。

4.  国家自然科学基金——国家基础科学人才培养基金子课题，基于肽类成分研究益母草缩宫止血的药效物质基础(J1310034-28)，2015/1-2017/12，主持。

5.  中国博士后科学基金，益母草中缩宫活性环肽的发现与研究(2014M562291)，2014/1-2016/12，主持。

6.  四川省应用基础研究项目，益母草活血调经、缩宫止血的活性成分研究(2012JYZ005)，2013/1-2015/12，主持。

7.  四川省川产道地药材综合开发与区域发展项目，川产道地药材（川芎）产业化发展示范县项目(2017ZY002)，2017/1-2019/12，主持。

8.  四川省教育厅自然科学重点项目，广藿香中广谱抗菌倍半萜的发现与研究(15ZA0084)，2015/1-2017/12，主持。

9.  国家自然科学基金重点项目，附子“毒与效”的多维评价与整合分析研究(81630101)，2017/1-2021/12，排名第2。

近年来以第一作者或通讯发表的SCI论文

Liang Xiong, Qin-Mei Zhou, Yike Zou, Ming-Hua Chen, Li Guo, Guan-Ying Hu, Zhao-Hua Liu, Cheng Peng*. Leonuketal, a spiroketal diterpenoid from Leonurus japonicus. Organic Letters, 2015, 17(24): 6238-6241.

Qin-Mei Zhou#, Ming-Hua Chen#, Xiao-Hong Li, Cheng Peng*, Da-Sheng Lin, Xiao-Nian Li, Yang He, Liang Xiong*. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin. Journal of Natural Products, 2018, 81(9): 1919-1927.

Fu Peng, Chun-Wang Meng, Qin-Mei Zhou, Jian-Ping Chen*, Liang Xiong*. Cytotoxic evaluation against breast cancer cells of isoliquiritigenin analogues from Spatholobus suberectus and their synthetic derivatives. Journal of Natural Products, 2016, 79(1): 248-251.

Liang Xiong, Mei Zhu, Chenggeng Zhu, Sheng Lin, Yongchun Yang, Jiangong Shi*. Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis. Journal of Natural Products, 2012, 75(6): 1160-1166.

Liang Xiong, Chenggeng Zhu*, Yanru Li, Ye Tian, Sheng Lin, Shaopeng Yuan, Jinfeng Hu, Qi Hou, Naihong Chen, Yongchun Yang, Jiangong Shi*. Lignans and neolignans from Sinocalamus affinis and their absolute configurations. Journal of Natural Products, 2011, 74(5): 1188-1200.

Hai-Guo Su, Qin-Mei Zhou, Li Guo, Yuan-Jin Huang, Cheng Peng*, Liang Xiong*. Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines. Phytochemistry, 2018, 156: 89-95.

Juan Liu, Cheng Peng*, Qin-Mei Zhou, Li Guo, Zhao-Hua Liu, Liang Xiong*. Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle. Phytochemistry, 2018, 145: 128-136.

Ya-Cong He, Cheng Peng*, Xiao-Fang Xie, Ming-Hua Chen, Xiao-Nian Li, Meng-Ting Li, Qin-Mei Zhou, Li Guo, Liang Xiong*. Penchinones A–D, two pairs of cis-trans isomers with rearranged neolignane carbon skeletons from Penthorum chinense. RSC Advances, 2015, 5(94): 76788-76794.

Yu-Lin He#, Jian-You Shi#, Cheng Peng*, Li-Jiao Hu, Juan Liu, Qin-Mei Zhou, Li Guo, Liang Xiong*. Angiogenic effect of motherwort (Leonurus japonicus) alkaloids and toxicity of motherwort essential oil on zebrafish embryos. Fitoterapia, 2018, 128: 36-42.

Huan Zhu#, Qin-Mei Zhou#, Cheng Peng*, Ming-Hua Chen, Xiao-Nian Li, Da-Sheng Lin, Liang Xiong*. Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin. Fitoterapia, 2017, 120: 67-71.

Chun-Wang Meng, Yu-Lin He, Cheng Peng*, Xing-Jie Ding, Li Guo, Liang Xiong*. Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect. Fitoterapia, 2017, 121: 206-211.

Liang Xiong, Qin-Mei Zhou, Cheng Peng*, Xiao-Fang Xie, Lu-Si Liu, Li Guo, Ya-Cong He, Lian Yang, Zhao-Hua Liu. Bis-spirolabdane diterpenoids from Leonurus japonicus and their anti-platelet aggregative activity. Fitoterapia, 2015, 100: 1-6.

Ya-Cong He, Yike Zou, Cheng Peng*, Jian-Lin Liu, Cheng-Jun He, Li Guo, Xiao-Fang Xie, Liang Xiong*. Penthorin A and B, two unusual 2,4′-epoxy-8,5′-neolignans from Penthorum chinese. Fitoterapia, 2015, 100: 7-10.

Juan Liu, Cheng Peng*, Cheng-Jun He, Jian-Lin Liu, Ya-Cong He, Li Guo, Qin-Mei Zhou, Huai Yang, Liang Xiong*. New amino butenolides from the bulbs of Fritillaria unibracteata. Fitoterapia, 2014, 98: 53-58.

Fu Peng, Liang Xiong*, Xiao-Mei Zhao. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules, 2013, 18(11): 13904-13909.

Liang Xiong, Cheng Peng*, Qin-Mei Zhou, Feng Wan, Xiao-Fang Xie, Li Guo, Xiao-Hong Li, Cheng-Jun He, Ou Dai. Chemical composition and antibacterial activity of essential oils from different parts of Leonurus japonicus Houtt. Molecules, 2013, 18(1): 963-973.

Liang Xiong, Qin-Mei Zhou, Cheng Peng*, Xiao-Fang Xie, Li Guo, Xiao-Hong Li, Juan Liu, Zhao-Hua Liu, Ou Dai*. Sesquiterpenoids from the herb of Leonurus japonicus. Molecules, 2013, 18(5): 5051-5058.

Liang Xiong, Zhi-Xing Cao, Cheng Peng*, Xiao-Hong Li, Xiao-Fang Xie, Ting-Mo Zhang, Qin-Mei Zhou, Lian Yang, Li Guo*. Phenolic glucosides from Dendrobium aurantiacum var. denneanum and their bioactivities. Molecules, 2013, 18(6): 6153-6160.

Liang Xiong, Cheng Peng*, Xiao-Fang Xie, Li Guo, Cheng-Jun He, Zhao Geng, Feng Wan, Ou Dai, Qin-Mei Zhou. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules, 2012, 17(8): 9939-9946.

Xiao Zhang, Li-Hua Zou, Yu-Lin He, Cheng Peng, Li Guo*, Liang Xiong*. Triterpenoid saponins from the buds of Lonicera similis. Natural Product Research, 2017, doi.org/10.1080/14786419.2017.1408092.

Zhong-Hui Pu, Juan Liu, Cheng Peng*, Min Luo, Qin-Mei Zhou, Xiao-Fang Xie, Ming-Hua Chen, Liang Xiong*. Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum. Natural Product Research, 2017, doi.org/10.1080/14786419.2017.1416382.

Ou Dai, Xiao-Hong Li, Qin-Mei Zhou, Cheng Peng*, Li Guo, Liang Xiong*. Sesquiterpenoids from the aerial parts of Pogostemon cablin. Phytochemistry Letters, 2018, 24: 56-59.

Yue Wang Ou Dai, Cheng Peng*, Hai-Guo Su, Lu-Lin Miao, Lu-Si Liu, Liang Xiong*. Polyoxygenated ergosteroids from the macrofungus Omphalia lapidescens and the structure-cytotoxicity relationship in a human gastric cancer cell line. Phytochemistry Letters, 2018, 25: 99-104.

Jian-lin Liu, Xiao-hong Li, Cheng Peng*, Da-sheng Lin, Ya-nan Wang, Yu-ting Yang, Qin-mei Zhou, Liang Xiong*. 4-nor-β-Patchoulene sesquiterpenoids from the essential oil of Pogostemon cablin. Phytochemistry Letters, 2015, 12: 27-30.

Qin-mei Zhou, Cheng Peng*, Huai Yang, Lu-si Liu, Yu-ting Yang, Xiao-fang Xie, Li Guo, Zhao-hua Liu, Liang Xiong*. Steroids from the aerial parts of Leonurus japonicus. Phytochemistry Letters, 2015, 12: 287-290.

Chun-Wang Meng, Cheng Peng*, Qin-mei Zhou, Huai Yang, Li Guo, Liang Xiong*. Spirostanols from the roots and rhizomes of Trillium tschonoskii. Phytochemistry Letters, 2015, 14: 134-137.

Xiao-Hong Li, Li Guo, Lian Yang, Cheng Peng*, Cheng-Jun He, Qin-Mei Zhou, Liang Xiong*, Juan Liu, Ting-mo Zhang. Three new neolignan glucosides from the stems of Dendrobium aurantiacum var. denneanum. Phytochemistry Letters, 2014, 9: 37-40.

Lian Yang, Cheng Peng*, Chun-Wang Meng, Cheng-Jun He, Xiao-Hong Li, Li Guo, Qin-Mei Zhou, Liang Xiong*. A new macrolide and six cycloartane triterpenoids from the tubers of Bletilla striata. Biochemical Systematics and Ecology, 2014, 57: 238-241.

Qin-Mei Zhou, Cheng Peng*, Xiao-Hong Li, Liang Xiong*, Cheng-Jun He, Li Guo, Zhi-Xing Cao, Zhao-Hua Liu. Aromatic compounds from Leonurus japonicus Houtt. Biochemical Systematics and Ecology, 2013, 51: 101-103.

Xiao-hong Li, Li Guo*, Cheng Peng, Jin-hui Bian, Ting-mo Zhang, Cheng-jun He, Qin-mei Zhou, Liang Xiong*. A New 8′,9′-Dinor 8,4′-Oxyneolignan Glucoside from Dendrobium Aurantiacum var. Denneanum. Records of Natural Products, 2016, 10(1): 113-116. 

近年来专著

熊亮（副主编）. 天然药物化学（全国普通高等中医药院校药学类专业“十三五”规划教材-第二轮规划教材）, 中国医药科技出版社, 2018/8, 北京.

熊亮（编委）. 天然药物化学实验（全国普通高等中医药院校药学类专业“十三五”规划教材-第二轮规划教材）, 中国医药科技出版社, 2018/8, 北京.

熊亮（副主编）. 经产良药益母草, 四川科学技术出版社, 2017/11, 成都.

获得奖励

经产良药益母草的多维评价与开发应用，四川省科技进步奖，一等奖，2017年（ 证书编号2017-J-1-19-R09）

乌头类有毒中药安全性评价模式的建立与示范，华夏医学科技奖，二等奖，2013年（证书编号201302120P1010）