【学习和工作经历】      

1996-1997 年，日本大阪大学理学部高分子科学系, 联合培养博士生      

1994-1999 武汉大学化学系高分子化学与物理专业, 获博士学位      

1999-2000 国家中药现代化工程技术研究中心, 工程师      

2000-2001 日本大阪大学蛋白质研究所, 客座研究员      

2001-2005 美国北卡大学药学院, 博士后研究员      

2005-2008 武汉理工大学化学工程学院制药工程系, 教授      

2006-2007 美国北卡大学药学院, 访问教授      

2009年至今江南大学药学院教授, 博士生导师。      

【主要学术兼职】      

美国化学会会员，国际糖生物学会会员。   

生物活性高分子、糖药物 

【近年来获得的学术科研成果】      

已获批国际专利2项，中国专利1项，正在申请国际专利1项，已公开中国专利20余项。      

【主要授权和公开专利】      

1、Enzymatic   synthesis of sulfated polysaccharides，国际发明专利，WO2006124801      

2、Purified and   isolated heparin sulfate 3-O-sulfotransferase isoform 5 nucleic acids and   therapeutic and screening methods using SAME isoform 5 nucleic acids and   therapeutic and screening methods using SAME，国际发明专利，WO2004005475。      

3、一种制备肝素修饰的金纳米粒子的方法，发明专利号，ZL200910024843.4      

【近年来主要研究课题】      

1.新型生物医用材料的研制, 新世纪优秀人才支持计划。      

2.酶法选择性改造肝素结构制备肝素衍生物及其抗凝血活性研究，教育部博士点基金。      

3.表面原位合成类肝素以提高生物材料血液相溶性研究，国家自然科学基金。      

4.蛋白质吸附行为与血液相容行生物高分子材料的制备，973前期专项子课题。      

5.新型抗凝血硫酸乙酰肝素的生物合成及生物活性，教育部回国留学人员启动基金。      

【近年来主要论文代表作】      

1.  C. Deng, H. Fu, L. Teng, Z. Hu, X. Xu, J. Chen*,   T. Ren, Anti-tumor activity of the regenerated triple-helical polysaccharide   from Dictyophora indusiata, International Journal of   Biological Macromolecules, 2013, 61, 453-458.

2.  J. Chen, J. Chen, J.   Song, Collagen-PVP hybrid based anti-inflammatory hydrogel for wound   repairing,Journal of Controlled Release, 2013, 172: e125.      

3.  C. Deng, Z. Hu, H. Fu, M. Hu, X. Xu, J. Chen*,   Chemical analysis and antioxidant activity in vitro of a β-D-glucan isolated from Dictyophora indusiata,International   Journal of Biological Macromolecules, 2012, 51(1-2), 70-75.      

4.  Y. Liu, L. Liu, J. Chen, J. Li, G. Du, J.   Chen, Effects of carbon sources and feeding strategies on heparosan   production by Escherichia coli K5,Bioprocess and Biosystems   Engineering, 2012, 35(7), 1209-1218.      

5.  G. Lu, L. Kai, P. Zhao, Z. Xu, C. Deng, H. Zheng, J.   Huang, J. Chen*, A novel in situ-formed hydrogel wound dressing by the   photocross-linking of a chitosan derivative,Wound repair and regeneration,   2010, 18(1), 70-79.      

6.  X. Zhang, J. Huang, P. Chang, J. Li, Y. Chen, D.   Wang, J. Yu, J. Chen, Structure and properties of polysaccharide   nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion,Polymer,   2010, 51(19), 4398-4407.      

7.  P. Xu, G. Guo, J. Huang, S. Zhou, D. Wang, J. Yu, J.   Chen, Alginate-based ferrofluid and magnetic microsphere thereof,International   Journal of Biological Macromolecules, 2010, 47(5), 654-660.      

8.  J. Wang, X. Xu, H. Zheng, J. Li, C. Deng, Z. Xu, J.   Chen*, Structural Characterization, Chain Conformation, and Morphology of   aβ-(1→3)-D-Glucan   Isolated from the Fruiting Body of Dictyophora indusiata,Journal   of Agricultural and Food Chemistry, 2009, 57(13), 5918-5924.      

9.  K. Ling, F. Zheng, J. Li, R. Tang, J. Huang, Y. Xu,   H. Zheng, J.Chen*, Effects of substitution degree of   photoreactive group on the properties on the UV-fabricated chitosan scaffold,Journal   of Biomedical Material Research (A), 2008, 87(1), 52-61.      

10. J. Chen, J.   Courtney, J. Liu, Using an enzymatic combinatorial approach to identify   anticoagulant heparan structures,Chemistry and Biology,   2007, 14, 986-993.      

11. J. Chen, F.Y. Avci,   E.M. Munoz et. al., Enzymatic redesigning of biologically active heparan   sulfate, Journal of Biological Chemistry, 2005, 280,   42817-25.      

12. G. Xia, J. Chen, V. Tiwari, W. Ju et. al.,   Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an   antithrombin-III binding site and an entry receptor for herpes simplex virus,   type 1,Journal of Biological Chemistry,2002, 277,   37912-37919.      

13. L.M McDowell，B.A.   Frazier，D.R. Studelska，K.   Giljum，J. Chen et.   al., Inhibition or activation of apert syndrome   FGFR2(S252W) signaling by specific glycosaminoglycans,   Journal of Biological Chemistry, 2006, 281, 6924-6930.      

14. A. Neigishi, J. Chen, D.M. MacCarty, R.J.   Samulski et. al., Analysis of the interaction between adeno-associated virus   and heparan sulfate using atomic force microscopy, Glycobiology,  2004, 14, 969-977.      

15. J. Chen, M.B.             Duncan , K. carrick, R.M.   Pope et. al., Biosynthesis of 3-O-sulfotransferase heparan sulfate: unique   substrate specificity of 3-O-sulfotransferase isoform 5, Glycobiology,2003,   13, 785-794.                  

16. J. Chen and J. Liu, Characterization of the structure of antithrombin-binding   heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5, Biochim   Biophys Acta, 2005, 1725, 190-200.     

17. M.B. Duncan, J Chen, J.P. Krise, J. Liu, The   biosynthesis of anticoagulant heparan sulfate by the heparan sulfate   3-O-sulfotransferase isoform 5, Biochim Biophys Acta,   2004, 1671, 34-43.     

18. V. Tiwari, C. Clement, M.B. Duncan, J. Chen, et.   al., A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes   simplex virus type 1,Journal of GeneralVirology, 2004, 85,   805-809.