Despite a large number of wound dressing materials in the market, an ideal dressing able to re-establish both the features and functions of the native skin remains a challenge. Concerning this, the present study aimed to produce a new double-layer nanofibrous dressing material. The upper layer was fabricated by using Poly(l-lactic acid; PLLA) to act as a hydrophobic protective barrier, while the highly porous lower layer composed of a blend of Poly(ethylene) oxide (PEO) and Chitosan (CS) containing Hypericum perforatum L. (HP) was produced to be used in the wound site, reduce the risk of infection, and enhance the healing process. The produced double-layer material exhibited the required chemical, physical, and mechanical properties. Besides, the results showed an inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa growth without providing any cytotoxicity on normal human dermal fibroblast (NHDF) cells. Therefore, these findings emphasize the potential use of this material as an antimicrobial wound dressing to treat skin lesions.
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