Wound healing is a complicated procedure which necessitates laying out a suitable wound healing system or dressing which possesses key factors like a wet wound location, avoidance of microbial action and absorption of exudates. Various wound dressings can be accessible but not all can meet the particular conditions of a perfect wound healing system to complete proper wound healing process. Poly(Lactic Acid) (PLA) Nano Structure Mats are a new class of materials that possess great potential in wound healing because of biocompatibility, bio absorbability, biodegradability, absorption of exudates from the wound, physical safety of the wounded tissue and the probability to free useful molecules. Our review article gives a brief intro on the wound and skin structure and afterwards gives information about the peerless characteristics of PLA Nano Structure Mats remarkable for wound healing. Moreover, new recent investigations about PLA Nano Structure Mats usage for wound healing applications were also explored.