BACKGROUND Thiabendazole (TBZ) is a poorly water-soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl-beta-cyclodextrin (TBZ/HP beta CD) complex was synthesized and electrospinning was performed to produce a TBZ/HP beta CD nanofibrous (TBZ/HP beta CD-NF) complex that improved water solubility and antifungal activity. RESULTS The formation of TBZ/HP beta CD-NF was characterized by Fourier transform infrared spectroscopy, X-ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HP beta CD-NF was studied by scanning electron microscopy. A phase solubility experiment showed that HP beta CD exerted a great solubilization effect on TBZ, and TBZ/HP beta CD-NF had better antifungal activity compared to that of TBZ alone. CONCLUSIONS In summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of agriculture.