Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications-易丝帮

Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications

2020/9/27 13:08:05 Furuno, K. Wang, J. Suzuki, K. Nakahata, M. Sakai, S.

Gelatin-based water-insoluble nanofibers with a diameter of 160 nm were obtained from electrospinning aqueous solutions containing gelatin with phenolic hydroxyl (Ph) moieties (Gelatin-Ph) and horseradish peroxidase (HRP). The water insolubility of the nanofibers was accomplished through HRP-catalyzed cross-linking of the Ph moieties by exposing the electrospun nanofibers to air containing hydrogen peroxide. The HRP activity in the electrospun nanofibers was 65% that of native HRP. The cytocompatibility necessary for tissue engineering applications of the water-insoluble Gelatin-Ph nanofibers was confirmed by the adhesion and viability of human embryonic kidney-derived HEK293 cells.

Journal: Acs Omega
Volume: 5
Issue:
Pages: 21254-21259
ISSN: 2470-1343
DOI:
Year: 2020
Number: 33
Type: Journal Article

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文献速递：南通大学徐思峻教授&葛建龙教授：防火/耐酸/耐碱芳纶/碳纳米纤维摩擦纳米发电机

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