In this work, a flexible, low cost, and cleanroom-free technique to fabricate barium titanate (BaTiO3) hybrid p-n homojunction-based multifunctional sensor for photodetection, strain sensing, and chemiresistive sensing is reported. The n-type BaTiO3 nanofibers are synthesized using electrospinning technique and deposited on the flexible indium tin oxide (ITO) using spin-coating method while p-type BaTiO3 nanoparticles are synthesized using modified sol-gel method and deposited using drop-casting method. Detailed characterization studies are performed to reveal the formation of tetragonal phase p-type nanoparticles and n-type nanofibers of BaTiO3 assembled on the ITO substrate. The fabricated hybrid junction photodetector displays an excellent external quantum efficiency of approximate to 3500 and photoresponsivity of approximate to 11 A W-1. Further, the hybrid junction when employed as strain sensor exhibits a gauge factor of 14 and when operated in chemiresistive sensing mode can detect alpha 1-acid glycoprotein with an excellent sensitivity of 49.7 mu m(-1) in the wide dynamic range of 0.05-10 x 10(-6) m and detection limit of 12 x 10(-9) m. Detailed studies to understand the underlying mechanism of operation for each application are done. The strategy outlined here can be further employed for sensing various physical and chemical stimuli, paving a new path for developing flexible multifunctional nanoelectronic devices.