The study aimed to prepare and evaluate carvedilol loaded polyvinylpyrrolidone (PVP) and polyethylene glycol 400 (PEG 400) electrospun nanofibers for sublingual drug delivery. The fabricated formulation was character-ized using scanning electron microscopy, Fourier transform infrared spectroscopy (FT-IR) and molecular docking techniques. Prepared nanofibers film was analyzed in terms of surface morphology, thickness, folding en-durance, and drug release profile. The results indicated that carvedilol was amorphous in the fibers form and an average diameter of 745 +/- 57 nm with a smooth cylinder cross-link structure. Both FT-IR and molecular docking studies demonstrated that hydrogen bonding contributed to drug-polymer intermolecular interaction. The drug dissolution and permeation were much higher than those of the physical mixture. Overall the devel-oped fast dissolving electrospun polymeric film is a promising delivery carrier for carvedilol sublingual delivery.