Electrospun nanofibrous membranes (NFMs) with outstanding photochromic property, waterproof, and breathability have attracted considerable interest owing to their multifunctional applications in intelligent clothing, self-cleaning, and protection. However, great challenges still remain in creating such functional materials. A novel waterproof-breathable membrane with robust photochromic property is fabricated by introducing photochromic microcapsule (PM) into electrospun thermoplastic polyurethanes (TPU) membranes. Compared with the pristine TPU NFMs, the composite TPU/PM membranes are endowed with reversible photochromic properties. In addition, the composite membranes not only exhibited a water contact angle of 137 degrees and a milk contact angle of 130 degrees, but also had integrated properties of modest water vapor transmittance rate of 19,278 gm(-2)day(-1), high air permeability of 962 mms(-1), low waterproofness of 2.813 kPa, and comparable tensile strength of 12.08 MPa. Furthermore, the convenience and efficiency of this fabrication process will allow for large-scale production of the multifunctional NFMs. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46342.