Polyurethane/poly(E >-caprolactone) (PU/PCL) scaffolds with various concentrations of PCL (0 to 40 wt%) were electrospun to evaluate the mechanical properties and the biocompatibility of the PU/PCL hybrid scaffolds. The 10 wt% PU/PCL scaffolds were chosen due to the absence of beads. The ultimate tensile strengths of 10 wt% PU and 15% PCL scaffolds were 8.0 +/- 1.3 MPa and 6.8 +/- 1.0 MPa. The tensile strength of PU/PCL scaffolds increased dramatically to 12.1 +/- 1.4 MPa when 10% PCL was added to PU. As the PCL content was raised to 20%, 30%, and 40%, the strength of PU/PCL scaffolds started to decrease to 8.9 +/- 1.1 MPa, 7.6 +/- 0.6 MPa, and 5.3 +/- 0.6 MPa, respectively. The highest strength was observed for the 90/10 PU/ PCL scaffolds and no cytotoxicity was detected.