Snail powders have many medicine functions. This paper uses the powders as additives for fabrication of nanofibers by the electrospinning and the bubble electrospinning, such work has never been studied before in any open literature. Unsmooth nanofiber is observed, and small fibers have higher acid-proof and alkali-proof properties, and their main reasons are revealed. Snail's slime involved in the powder has a fast immobilization property, and the immobilization process will blocks surface motion of the spun jets during the spinning process. Potential applications of the unsmooth nanofibers are predicted. (C) 2018 Elsevier B.V. All rights reserved.