The flexible ZnO/SiO2 hybrid nanofiber membrane was prepared via electrospinning followed by high-temperature annealing at 600 degrees C in the air. The hybrid membrane was researched to prepare a flexible pressure sensor, and the experimental results suggest that the flexible pressure sensor has excellent flexibility under different bending conditions. The sensitivity (I-max/I-0) of ZnO/SiO2 hybrid nanofibers is about 12.75 when the blending curvature radius is 1.25 cm(-1). Among them, I-max means current value when the sample is bending with curvature of 1.25 cm(-1) at a voltage of 30 V, and I-0 means current value when the sample is relaxing at a voltage of 30 V. Besides, the prepared nanofibers have excellent pressure sensibilities under various pressures, and the sensitivity (I-max/I-0) is up to 20.12 under 32.60 kPa pressure. In addition, the sensor exhibits high sensitivity, reversibility/reproducibility and good performance. The energydispersive x-ray spectroscopy shows that atomic percentage of Si to Zn was 43.9%. Additionally, it can be observed from the PL (photoluminescence spectrum) pattern that the sample has fine surface performance. The mechanisms of flexibility and pressure sensitivity are investigated. These results indicate that flexible ZnO/SiO2 hybrid nanofiber films have a bright future in the field of flexible electronic devices.