Melt-Blown and Electrospun Drug-Loaded Polymer Fiber Mats for Dissolution Enhancement: A Comparative Study
2019/11/27 21:40:39
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Melt blowing (MB) was investigated to prepare a fast dissolving fibrous drug-loaded solid dispersion and compared with solvent-based electrospinning (SES) and melt electrospinning (MES). As a conventional solvent-free technique coupled with melt extrusion and using a high-speed gas stream, MB can provide high-quality micro- and nanofibers at industrial throughput levels. Carvedilol, a weak-base model drug with poor water solubility, was processed using a common composition optimized for the fiber spinning and blowing methods based on a hydrophilic vinylpyrrolidone-vinyl acetate copolymer (PVPVA64) and PEG 3000 plasticizer. Scanning electron microscopy combined with fiber diameter analysis showed diameter distributions characteristic to each prepared fibrous fabrics (the mean value increased toward SES
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Advanced Fiber Materials DOI:10.1007/s42765-023-00288-2
林佳弘，逢甲大学特聘教授、博士生导师；兼任中国医药大学教授，天津工业大学特聘教授，青岛大学客座教授，“闽江学者”讲座教授，Polymers特刊主编，及多家国际期刊审查委员。 专研纤维与纺织、功能性纺织品、医疗与保健、生医与纳米、能源与环境复合材料。“Nonwoven Engineering”领域国际期刊量超过300篇，居全世界第1名学术荣誉学者；2017年入选全世界前1％科学家。
代云茜，东南大学教授、博士生导师。江苏省六大人才高峰入选者、江苏省科协青年托举工程入选者，担任中国复合材料学会超细纤维分会副主任委员、多家国际著名学术期刊审稿人。
