Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymer onto sintered 45S5 Bioglass (R)-based glass-ceramic pellets. The investigated polymers were (polyhydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL-PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning pro parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofit In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and minimisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nano fiber-coated HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to the the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds. (C) 2009 Elsevier B.V. All rights reserved.