In consideration of the strong volatility and chemical instability of eugenol, liposomes were introduced to remain the activity of eugenol during processing and storage. Silica nanoparticle (SiO2) was used to adsorb eugenol before liposome encapsulation for getting better physicochemical properties and physical stability. The results of particle size, zeta potential and encapsulation efficiency of liposomes containing SiO2-eugenol were 315.7 +/- 0.7 nm, -47.7 +/- 0.3 mV, and 89.91 +/- 0.43%, respectively. The experiments testing the physical stability of liposomes containing SiO2-eugenol showed that SiO2 could significantly promote its stability. For the application in food antioxidant, electrospun nanofibrous membranes were introduced to immobilize the SiO2-eugenol liposomes. In this study, the antioxidant assay of SiO2-eugenol liposome loaded nanofibrous membranes exhibited antioxidant activity on beef. (C) 2017 Elsevier Ltd. All rights reserved.