Fast and large-scale production of mesoporous titania nanofibers was achieved by solution blow spinning. The blow spinning setup provides a method to prepare titania nanofibers in a safe and scalable way without using a high-voltage electric field. Titania microstructure and porosity can be modified by adding a suitable template, such as pluronic polymers. The blow spun titania nanofibers had a good performance on the photocatalytic degradation of tetracycline and could be easily removed from the tetracycline aqueous solution due to their large aspect ratio. Solution blow spinning method has a great potential for the large-scale production of titania nanofibers with good photocatalytic properties.