The current landscape of bone regeneration research has focused on novel processing techniques for scaffolds and the employment of nanostructured and bioactive materials to trigger specific cell function in osteogenic way. The investigation of novel technological methods and materials may guide towards more promising and still unexplored strategies to fabricate innovative scaffolds for hard tissue regeneration. Here, we focus on recent advancements in the area of tissue-engineered scaffold fabrication with emphasis on polymer/ceramic composites and micro and/or nanotexturing processes (i.e, electrospinning) as well as their combinations. In particular, different approaches based on the design of bioactive micro/nanonanocomposites, hybrids and nanofibers will be presented with some promise for engineering three-dimensional ECM analogues of bone.