Plant grafting is a well-known activity in orchards, greenhouses and vineyards gardens. However, low survival rate still limits the promotion of grafting and breeding of improved varieties. We report on polymeric fibers, obtained through coaxial electrospun, as carriers for the sustained release of drugs to heal wounds in plants. The CA-PU co-electrospun fibers show a rather uniform diameter, a smooth and hydrophilic surface. As long as 10 days of sustained drugs release meets with the physiological requirement of plant grafting. The callus toxicity test shows that the CA-PU fibers are not toxic for plant cells. We show that loading the core of CA-PU fibers with 6-Benzylaminopurine (6-BA), a first-generation synthetic cytokinin that elicits plant growth and development, results in fibers that can efficiently promote the healing of plant wounds, thereby significantly improving the grafting survival rate. (C) 2017 Elsevier Ltd. All rights reserved.