Electrospun nanofiber technology bridges the gap between deterministic laws (Newton mechanics) and probabilistic laws (quantum mechanics). Our research reveals that. fascinating phenomena arise when the diameter of the electrospun nanofibers is less than 100 nm. The nano-effect has been demonstrated for unusual strength, high surface energy, surface reactivity, high thermal and electric conductivity. Dragline silk is made of many nano-fibers with diameter of about 20 nm, thus it can make full use of nano-effects. It is a challenge to developing technologies capable of preparing for nanofibers within 100 nm. Vibration-melt-electrospinning is uniquely qualified to address this challenge. The flexibility and adaptation provided by the method have made the method a strong candidate for producing nanofibers on such a scale. The application of Sirofil technology to strengthen nanofibers is also addressed, E-infinity theory is emphasized as a challenging theory for nano-scale technology and science. (c) 2006 Elsevier Ltd. All rights reserved.