Laser melt electrospinning is a novel technology to produce nonwoven scaffolds for tissue engineering (TE) applications. This solvent-free process is far safer than common solution electrospinning. In this paper, we demonstrated the poly(E-caprolactone) (PCL) fibers diameters could be governed from 3 to 12 pm with changing electrospinning parameters. The various diameters can meet the needs of scaffold properties such as porosity, pore size, etc. Our experiential results also showed that the fibers diameter tended to decrease as laser current increased. The degradation of PCL molecular chains often occurs in the melt electrospinning process due to mechanical scission and thermal degradation. The crystallinity of as-spun PCL fibers was approximately equal to that of the annealing fibers by X-ray diffraction (XRD) and differential scanning calorimetry (DSC). In our experiential, the collected PCL electrospun fibers often fused together to form a three-dimension network structure, which is favorable to mechanical properties. (C) 2011 Elsevier Ltd. All rights reserved.