Electrospun core shell fibers have gained increasing popularity in biomedical applications ranging from tissue regeneration to wound healing. Uniform fiber morphology and well-defined core shell structure are critical for controlled delivery of bioactive molecules for these applications. In this work, core shell fibers with rat tail collagen type I as the shell and a model protein, bovine serum albumin, as the core were prepared using coaxial electrospinning in both the horizontal and vertical configurations. High speed photography was used to observe the formation of the Taylor cone and fiber whipping motion during the fiber spinning process. Morphological considerations and core shell structure of the fibers indicated that the vertical configuration is preferred for core shell fiber preparation. The electrospun core shell collagen fibers prepared using optimized experimental setup and parameters and crosslinked using genipin also demonstrated good cell compatibility properties.