Ricinoleic Acid Encapsulation into Ethyl Cellulose Electrospun Fibers
2019/11/27 21:28:56
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Ricinoleic acid (RA), non-irritant, shows a pro- or anti-inflammatory action following its topical application. However, RA goes rancid when it is exposed to oxygen. Encapsulation of RA into ethyl cellulose (EC) electrospun fibers is the approach. RA was extracted from castor oil and characterized. Electrospinning parameters of EC, dissolved in 2:3 dimethylformamide:acetone, were optimized to obtain bead-free fibers. A 1-8 mu m EC fibers were obtained at 20 kV, 0.5mL/h feeding rate, and 20cm air gap. RA at different concentrations was encapsulated into EC fibers. Release profile was reported and encapsulation was demonstrated via morphological analysis.

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