In this study, nanofibers of poly(lactic-co-glycolic acid) with a core-shell structure encapsulating epidermal growth factor (EGF) were prepared through emulsion electrospinning technique. The morphology and the core-shell structure of the nanofibers were observed by field emission scanning electron microscopy and transmission electron microscopy, respectively. The release profile of EGF indicated a continuous release of the protein over one week. Biocompatibility of the plasma-treated scaffolds was evaluated using MTT assay for human fibroblast cells. The results demonstrated desirable biocompatibility and bioactivity of the scaffolds with the capability of encapsulation and controlled release of EGF which can be utilized in skin tissue engineering applications.