In this study, we developed an esophageal stent capable of sustained delivery of an anticancer drug, fluorouracil (5-FU). The stents were coated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanofibers (DPN) via the electrospinning method, which exhibited a sustained drug release for up to 6 days. To prolong drug release, we also added the nanofiber layers composed of PLGA alone (PN), surrounding the DPN layer, as a more resistive diffusion barrier, where a period of drug release could be extended to 21 days with the DPN layer topped with another 192 mu m thick PN layer. Therefore, we envisioned longer period of drug release with the thicker PN layers, obtained simply with a longer collection time of PLGA nanofibers via electrospinning. Overall, we concluded that the drug-delivery esophageal stent prepared in this study is promising in the long-term treatment of dysphagia caused by esophageal cancer.