A composite of Ni-ZnO/rGO/nylon-6 electrospun nanofiber decorated by Ag nanoparticles was successfully introduced as a novel hybrid material with good visible light-driven photocatalytic and antibacterial properties having potential for repeated use. The Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), scanning electron microscopy (SEM), UV-vis diffuse reflectance spectroscopy (DRS) and thermogravimetric analysis (TGA) measurements were employed to characterize the phase structure, morphology, optical properties, and thermal stability of the as-synthesized composite. The results confirmed the successful incorporation of Ni-ZnO/rGO nanocomposite into the electrospun nylon-6 fibers as well as deposition of Ag nanoparticles on the surface of fibers. The effective photodegradation of methyl orange (MO) dye under visible light was demonstrated under the visible-light irradiation. Owing to the rational design and special structure of Ni-ZnO/rGO/nylon-6/Ag nanofibers, this new hybrid provides an efficient electron-hole separation to further react with adsorbed dye molecules and degrade them into non-toxic products. Furthermore, the antibacterial properties of the nanofibers were investigated against Escherichia coli (Gram-negative) and Bacillus Subtilis (Gram-positive) bacteria and excellent antibacterial activities against both studied bacteria were found. This work offers a new class of inorganic/organic nanocomposites with promising efficiency as good economically and environmentally friendly candidates for visible light-driven photocatalysis and water filter media. (C) 2017 Elsevier B.V. All rights reserved.