Current therapies for tissue malfunctioning or tissue loss have limitations in restoring the physiological functions and structural features of the damaged tissue in vivo. Circumventing these challenges, researchers are exploring options of producing tissue substitutes that can restore the function of damaged tissue. Several techniques have been used to produce biologically active scaffolds. In this investigation, we have used electrospinning technique to fabricate starch-based nanofibrous scaffolds. Starch is a biodegradable and versatile polymer. It's low cost, wide availability, non-toxicity, biocompatibility and tissue - healing ability make it a suitable candidate for tissue engineering applications. It also supports cell adhesion, proliferation and differentiation. Poly vinyl alcohol (PVA) was blended for improving mechanical properties of nanofibrous mat. Further, the mats were chemically cross-linked to improve their mechanical strength and water stability. Loading of the nanofibers with silver nanoparticles imparted them anti-bacterial activity. Overall, the developed scaffolds have potential to serve as a template for soft tissue engineering.