400-8910-119
首页 > 文献资料 > ES-Bank > 详情
Alkali-Mediated Miscibility of Gelatin/Polycaprolactone for Electrospinning Homogeneous Composite Nanofibers for Tissue Scaffolding
2019/11/27 21:19:27 Zhou, Q. H., H. L. Zhang, Y. Zhou, Z. P. Yu, H. H. Yuan, B. Feng, P. van Rijn and Y. Z. Zhang
Electrospun natural-synthetic composite nanofibers, which possess favorable biological and mechanical properties, have gained widespread attention in tissue engineering. However, the development of biomimetic nanofibers of hybrids remains a huge challenge due to phase separation of the polymer blends. Here, aqueous sodium hydroxide (NaOH) solution is proposed to modulate the miscibility of a representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) for electrospinning homogeneous composite nanofibers. Alkali-doped GT/PCL solutions and nanofibers examined at macroscopic, microscopic, and internal molecular levels demonstrate appropriate miscibility of GT and PCL after introducing the alkali dopant. Particularly, homogeneous GT/PCL nanofibers with smooth surface and uniform diameter are obtained when aqueous NaOH solution with a concentration of 10 m is used. The fibers become more hydrophilic and possess improved mechanical properties both in dry and wet conditions. Moreover, biocompatibility experiments show that stem cells adhere to and proliferate better on the alkali-modified nanofibers than the untreated one. This study provides a facile and effective approach to solve the phase separation issue of the synthetic-natural hybrid GT/PCL and establishes a correlation of compositionally and morphologically homogeneous composite nanofibers with respect to cell responses.
  • Journal: Macromolecular Bioscience
  • Volume: 17
  • Issue: 12
  • Pages:
  • ISSN: 1616-5187
  • DOI: 10.1002/mabi.201700273
  • Year: 2017
  • Number:
  • Type:
相关推荐
暂无相关推荐
网友评论 请遵循相关法律法规,理性发言
回复
查看更多回复

分享

为了更好的浏览体验,请使用谷歌,360极速,火狐或Edge浏览器